By Christoph Stein, Christoph Stein
This quantity makes an attempt to summarize the present country of data on mechanisms underlying a few of the results of analgesics, their part influence profiles, and their symptoms and contraindications in medical use. It additionally provides insights into present efforts to find novel mechanisms underlying the iteration of alternative forms of soreness and the ensuing improvement of recent modulating compounds.
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Additional info for Analgesia
Neuropathic pain, musculoskeletal pain) is controversial. Despite the fact that many patients have received opioids chronically (Portenoy et al. 1991), we do not really know how well they work. Opioid efﬁcacy in musculoskeletal pain and neuropathic pain has been claimed in a number of case reports and uncontrolled open studies. Few controlled studies investigating the efﬁcacy and side effects of opioids in these clinical settings are available (Caldwell et al. 1999; Moulin et al. 1996; Peloso et al.
Proc Natl Acad Sci USA 98:711–716 Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002) Superﬁcial NK1expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 5:1319–1326 Treede RD, Kenshalo DR, Gracely RH, Jones AKP (1999) The cortical representation of pain. Pain 79:105–111 Urban L, Thompson SWN, Dray A (1994) Modulation of spinal excitability: cooperation between neurokinin and excitatory amino acid transmitters. Trends Neurosci 17:432–438 Urban MO, Gebhart GF (1999) Supraspinal contributions to hyperalgesia.
2 Physical Dependence . . . . . . . . . . . . . . . . 53 53 54 References . . . . . . . . . . . . . . . . . . . . 54 Abstract Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors.