By R. Steiner (auth.), Dr. Rudolf Steiner, Dr. Paul B. Weisz, Dr. Robert Langer (eds.)

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Additional info for Angiogenesis: Key Principles — Science — Technology — Medicine

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It is an obvious future step to evolve suitable cell culture models for such diagnostic investigations and future developments for diagnostic practice. Balancing the future There is natural reluctance to turn to in vitro models of inherently lower level of complexity than is assumed to be operative in the in vivo environment. However, there is a current trend to seeing some unifying truths, such as many detailed variants of factors that might easily be lumped into one promoting category, and similar developments regarding GAG properties, etc.

47 degenerated or are destructed prior to fusion and structural stabilization, however, indicates that only a small amount of vascular sprouts is finally effectively attached and perfused. Reconstructive serial sections have shown that, on average, sprout fusion takes place over a distance of 10-15 Jim (Fig. 8). This is, however, not to be confused with the length of newly formed stretches of vessels, which are considerably longer. However, since the endothelia involved in sprout formation differentiate very rapidly, only the cells at the tip of the sprout reveal their characteristic features: the endothelium becomes higher, and the slit-like lumina become more tighter.

However, since the endothelia involved in sprout formation differentiate very rapidly, only the cells at the tip of the sprout reveal their characteristic features: the endothelium becomes higher, and the slit-like lumina become more tighter. Depending on the stage of fusion, more or less distinctly pronounced cell contacts can be shown amongst the endothelia involved. Network formation The angiogenic activity mentioned results in a characteristic vascular architecture [2, 11], as studied by corrosion cast specimens.

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